Nov 04

Apixaban in atrial fibrillation

In AF most on patients warfarin are unable to continue due to difficulty with regular monitoring. Dabigatran is an approved alternative anticoagulant for these patients.

In addition, apixaban, a factor Xa inhibitor is being tested.

In the AVERROES trial, 5599 AF patients were randomly assigned to either apixaban or aspirin. The study was stopped prematurely because of a clear benefit in favor of apixaban (lower rate of stroke or systemic embolism).

[N Engl J Med 2011; 364:806.]

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