Monthly Archive: April 2012

Apr 30

Statins Prior To CABG Reduce The Risk Of Postop AF

Statins administered prior to cardiac surgery significantly reduced the risk of postoperative atrial fibrillation and resulted in a significantly shortened length of stay in the intensive care unit (ICU), according to the results of a new meta-analysis. Preoperative statin therapy had no effect on short-term mortality and postoperative stroke rates, however. [Dr Oliver J Liakopoulos …

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Apr 30

ACE Inhibitors better ARBs in New Meta-Analysis in Hypertensives

A new meta-analysis has shown that use of ACE inhibitors is associated with a 10% reduction in all-cause mortality in hypertensive patients, compared with contemporary therapy that included blood-pressure lowering with drugs other than ACE inhibitors or angiotensin-receptor blockers (ARBs). In contrast, ARBs had a neutral effect on deaths, note Dr Laura C van Vark …

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Apr 30

PET/CT Helps Diagnose Cardiac Device Infection

PET/CT imaging can help distinguish between active infection of a cardiac electronic device and normal residual post-implant inflammation, a small study found. (Source: Medpage Today)

Apr 30

Atrial Fibrillation Should Be Surgically Treated When Performing Cardiac Surgery, Study Suggests

A recent study conducted by Northwestern Medicine® researchers published in the Journal of Thoracic and Cardiovascular Surgery, reveals that patients with an abnormal heart rhythm known as atrial fibrillation (A-fib) who are undergoing cardiac surgery, have a lower long-term survival rate compared with patients who are in sinus rhythm, which is the normal beating of the heart. The …

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Apr 30

Chlamydia Pneumonia as An Infectious Agent To Induce Heart Disease

Epidemiological findings have demonstrated an association of C. Pneumonia with coronary artery disease. LDL receptor deficient mice nasally infected with C. pneumonia will also generate plaque formation in an accelerated rate in comparison to controls. The atherogenic action of C. Pneumonia infection was only observed in a high cholesterol environment. The effects of C. Pneumonia …

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Apr 29

Cardiovascular Risk Assessment In Women

Most women do not perceive cardiovascular disease as an important health concern and report that they are not well informed about their cardiovascular risks. Cardiovascular disease in women is the main cause of morbidity and mortality, accounting for over 50% of all female deaths in Westernised countries. Cardiovascular risk factors are frequently missed and often …

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Apr 29

Genetic And Molecular Links Of Chromogranin A With Cardiovascular Disease States

Despite extensive research over the past several decades, molecular mechanisms of cardiovascular diseases remain poorly understood. Therefore, investigations on the genetic and molecular bases of cardiovascular diseases are ongoing in order to identify and characterize the susceptibility genes and their protein/peptide products. Recent studies showed that the circulating level of chromogranin A (a major protein …

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Apr 29

Implications Of No-Reflow Phenomenon In Acute Myocardial Infarction

The term “no reflow” describes a condition of myocardial tissue hypoperfusion in presence of patency of the epicardial circulation. The pathogenetic mechanism of no-reflow are not completely known, although it seems clear that this phenomenon comes form multifactorial pathogenetic events some components appear to playa key role: distal embolization of thrombotic atherosclerotic material, ischemia-reperfusion and …

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Apr 28

Smoking and Obesity Do Not Go Together

Obese people should not smoke as the combination may be deadly. Smoking and obesity are independent predictors of mortality, but smoking and being obese especially increase the mortality risk as per the American Journal of Clinical Nutrition. Obese smokers have a six to eight times greater risk of dying compared with normal weight people who …

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Apr 28

Pharmacogenetics In Cardiovascular Disorders

Pharmacogenomics, a revolutionary chapter in the history of pharmacology, has received new impetus from the development and accessibility to genome sequence and molecular biotechnologies, like DNA chips. The longstanding notion of responders/non-responders has given way to a more organic approach, where idiosyncrasy becomes an obsolete concept. This is a major step towards predictive, individualized medicine. …

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