Jul 25

History of heart failure indicates poor survival post-CABG

n a study published online July 13, 2016 in JAMA Cardiology, a history of heart failure (HF) was an important risk factor for poor short-term and long-term outcomes after CABG regardless of preoperative ejection fraction (EF). Reduced EF more than doubled the risk of early death after CABG. All-cause mortality 30 days after surgery was 0.8% in patients with no HF and pEF (n=27,165), and 2.9%, 2.8%, and 4% in those with no HF and rEF, HF with preserved ejection fraction (HFpEF) and HF with reduced ejection fraction (HFrEF). The study was based on all 41,906 patients in the SWEDEHEART registry who underwent primary isolated CABG between January 2001 and December 2013.

Jul 24

Assessing the clinical profile and prognosis in patients with heart failure with recovered ejection fraction

A recent study evaluated whether patients with heart failure who recover left ventricular ejection fraction (Rec-HF) have a distinct clinical profile and prognosis in contrast to those with heart failure and reduced left ventricular ejection fraction or heart failure and preserved left ventricular ejection fraction. The results printed in the journal of Cardiology showed that Rec-HF was present in the elderly patients. These patients had a better functional status. Moreover, the prevalence of diabetes mellitus, cerebrovascular disease and dementia was lower while that of chronic obstructive pulmonary disease was higher. Heart failure in these patients was more frequently ischemic and related to alcohol abuse than hypertension.

Jul 22

Treating HFrEF with sacubitril/valsartan reduces all-cause and heart-failure readmissions

Findings based on data from the Prospective Comparison of ARNI With an ACE-Inhibitor to Determine Impact on Global Mortality and Morbidity in Heart Failure (PARADIGM-HF) trial show that treating patients with heart failure and reduced ejection fraction (HFrEF) with the angiotensin receptor-neprilysin inhibitor (ARNI) sacubitril/valsartan (Entresto, Novartis) led to a 26% lower rate of 30-day readmission for any cause and a 38% lower rate of 30-day readmission for HF vs those treated with the ACE inhibitor enalapril. The study is published online July 11 in the Journal of the American College of Cardiology.

Jul 16

Long sedentary time increases risk of cardiovascular disease

A meta-analysis of prospective cohort studies found a nonlinear association with cardiovascular disease (CVD) such as coronary heart disease, myocardial infarction, stroke, and CVD-related death, suggesting that 10 hours a day might be a critical threshold. Compared with low levels of sedentary time (median 2.5 hours per day), intermediate levels (median 7.5 hours per day) were not linked to increased risk for CVD, but high levels with a median 12.5 hours per day were. These findings re reported online July 13, 2016 in JAMA Cardiology.

Jul 12

Analyzing the risk of atherosclerotic cardiovascular disease in individuals with familial hypercholesterolemia

Recently, an analysis was conducted in the individuals of the United States with a heterozygous familial hypercholesterolemia (FH) phenotype to determine the long-term risk of coronary heart disease (CHD) and total atherosclerotic cardiovascular disease (ASCVD). The FH phenotype was defined by a low-density lipoprotein (LDL) cholesterol concentration of ≥ 190 mg/dl while the referent value was less than 130 mg/dl. The results printed in the Circulation journal showed a considerable burden of the long-term ASCVD related to phenotypic FH. Thus, it is important to conduct FH screening for improving increased LDL concentrations, and in turn reducing CHD and ASCVD.

Jul 12

Mortality and tachyarrhythmic episodes of variant angina with and without aborted sudden cardiac death

A multicenter retrospective analysis that assessed the long-term mortality and ventricular tachyarrhythmic events of variant angina with and without aborted sudden cardiac death revealed remarkably higher incidence of cardiac death in patients with aborted sudden cardiac death than in those who did not experience it. Moreover, during the follow up period, the rate of cardiac death was comparatively lesser in patients with implantable cardioverter-defibrillators (ICD) than in those who did not receive ICD, the results have been published in the Journal of the American College of Cardiology.

Jul 12

Cardiovascular risk factors impact duration of hospitalization and mortality in ACS patients

According to a study reported June 26, 2016 in the International Journal of Cardiology, risk factors for cardiovascular disease such as diabetes, both type 1 and 2, hypertension, hyperlipidemia have a significant and varied impact on duration of hospitalization and mortality in patients with acute coronary syndrome (ACS) and it may be inappropriate to group them when assessing in-hospital risk. These factors should be used to identify patients at an increased risk of prolonged admissions and death post-ACS, and services should be directed accordingly.

Jul 07

Men are at greater risk of sudden cardiac death than women

Results from the long-running Framingham Heart Study published June 29, 2016 in the Journal of the American Heart Association says that men have at least twice the risk of dying from sudden cardiac death (SCD) than women, at all ages. Those with greater aggregate risk factor burden, or blood pressure level alone had a higher lifetime risks for sudden cardiac death.

Jul 04

Role of 2D speckle-tracking echocardiography in identifying left atrial strain in heart failure with preserved ejection fraction

Two-dimensional speckle-tracking echocardiography (2D-STE) has recently emerged as a useful tool for quantifying left atrium deformation dynamics. The current study published in the Herz Journal assessed the use of this tool in diagnosing heart failure with preserved ejection fraction as this syndrome is associated with impaired left atrial volume and function. The results established the efficacy of 2D-STE in identifying impaired left atrial function in patients with heart failure with preserved ejection fraction. Moreover, it was suggested that a global longitudinal left atrial strain during ventricular systole (GLAs-res) value of less than 17.5 % could be used for identifying this syndrome.

Jul 03

Family history biggest predictor of cardiac events in people with psoriasis

People with psoriasis are more likely to suffer myocardial infarction and stroke when they have a family history of cardiovascular problems, says a new Danish study reported in the Journal of the American Academy of Dermatology, online June 7. And, psoriasis was not found to be associated with a higher risk of MI or stroke when they had a negative family history of cardiovascular disease.

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